2015
Ahner A, Frizzell RA. SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?. Curr Drug Targets. 2015;16(9):965-75. PMID: 26028049.
Brodsky JL, Frizzell RA. A combination therapy for cystic fibrosis. Cell. 2015 Sep 24;163(1):17. PMID: 26406363 PMCID: PMC4865247
Deslouches B, Steckbeck J, Craigo J, Doi Y, Burns J, Montelaro R. Engineered cationic antimicrobial peptides (eCAPs) to overcome multidrug resistance by ESKAPE pathogens. Antimicrob Agents Chemother. 2015 Feb 59(2);1329-1333. PMID: 25421473 PMCID: PMC4335883.
Heidrich E, Carattino MD, Hughey RP, Pilewski JM, Kleyman TR, Myerburg MM. Intracellular Na+ regulates epithelial Na+ channel maturation. J Biol Chem. 2015 May 1;290(18):11569-77. PMID: 25767115 PMCID: 4416860
Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH. Enhancing autophagy with drugs or lung-directed gene therapy reverses the pathological effects of respiratory epithelial cell proteinopathy. J Biol Chem. 2015 Dec 11;290(50):29742-57. PMID: 26494620 PMCID:PMC4705969
Khanal A, Sharma R, Corcoran TE, Garoff S, Przybycien TM, Tilton RD. Surfactant Driven Post-Deposition Spreading of Aerosols on Complex Aqueous Subphases 1: High Deposition Flux Representative of Aerosol Delivery to Large Airways. J Aerosol Med Pulm Drug Deliv. 2015 Oct;28(5):382-93. PMID: 25723759 PMCID: PMC4601627.
Kumar P, Bhattacharyya S, Peters KW, Glover ML, Sen A, Cox RT, Kundu S, Caohuy H, Frizzell RA, Pollard HB, Biswas R. miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells. Gene Ther. 2015 Nov;22(11):908-16. PMID: 26133785 PMC Journal in Process
Lakdawala SS, Jayaraman A, Halpin RA, Lamirande EW, Shih AR, Stockwell T, Lin X, Simenauer A, Hanson C, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das S, Wentworth D, Sasisekharan R, Subbarao K . The Soft Palate is an Important Site of Adaptation for Transmissible Influenza Viruses. Nature. 2015, Oct 1;526(7571):122-5. PMID: 26416728 PMCID: PMC4592815
Nguyen NL, Pilewski JM, Celedón JC, Mandalapu S, Blanchard ML, DeRicco A, Hartigan E, Alcorn JF, Kolls JK. Vitamin D supplementation decreases Aspergillus fumigatus specific Th2 responses in CF patients with aspergillus sensitization: a phase one open-label study. Asthma Res Pract. 2015; Jun 4. PMID: 27011794 PMCID: PMC4801182.
Raundhal M, Morse C, Khare A, Oriss TB, Milosevic J, Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A. High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015 Aug 3;125(8):3037-50. PMID: 26121748 PMCID: PMC4563754
Ray M, Horne W, McAleer JP, Ricks DM, Kreindler JL, Fitzsimons MS, Chan PP, Trevejo-Nunez G, Chen K, Fajt M, Chen W, Ray A, Wenzel S, Kolls JK. RNA-seq in Pulmonary Medicine: How Much Is Enough? Am J Respir Crit Care Med. 2015 Aug 1;192(3):389-91. PMID: 26230238 PMCID: PMC4584249
Robinson KM, Kolls JK, Alcorn JF. The immunology of influenza virus-associated bacterial pneumonia. Curr Opin Immunol. 2015 Jun;34:59-67. PMID: 25723597; PMCID: PMC4444379.
Shanks RMQ,Stella NA, Hunt KM, Brothers KM, Zhang L, Thibodeau PH. Identification of SlpB, a Cytotoxic Protease from Serratia marcescens. Infect Immun. 2015 Jul;83(7):2907-16. PMID: 25939509 PMCID: PMC4468537.
Sharma R, Khanal A, Corcoran TE, Garoff S, Przybycien TM, Tilton RD. Surfactant Driven Post-Deposition Spreading of Aerosols on Complex Aqueous Subphases 2: Low Deposition Flux Representative of Aerosol Delivery to Small Airways. J Aerosol Med Pulm Drug Deliv. 2015 Oct;28(5):394-405. PMID: 25757067 PMCID: PMC4601626.
Vikram A, Bomberger JM, Bibby KJ. Efflux as a Glutaraldehyde Resistance Mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa Biofilms. Antimicrob Agents Chemother. 2015 June, 59(6): 3433-40. PMID: 25824217 PMCID: PMC4432172
Zemke AC, Gladwin MT, Bomberger JM. Sodium nitrite blocks the activity of aminoglycosides against Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2015;59(6):3329-34. PMID: 25801569 PMCID: PMC4432197.
2014
Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA Jr, Madden DR. Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. J Biol Chem. 2014 Jan 28. PMID: 24474692 PMCID: PMC3953260
Bomberger JM, Coutermarsh BA, Barnaby RL, Sato JD, Chapline MC, Stanton BA. Serum and Glucocorticoid-Inducible Kinase1 Increases Plasma Membrane wt-CFTR in Human Airway Epithelial Cells by Inhibiting Its Endocytic Retrieval. PLoS One. 2014 Feb 21;9(2). PMID: 24586903 PMCID: PMC3931797
Bomberger JM, Ely KH, Bangia N, Ye S, Green KA, Green WR, Enelow RI, Stanton BA. Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation. J Biol Chem. 2014 Jan 3;289(1):152-62. PMID: 24247241 PMCID: PMC3879540
Brodsky JL. The threads that tie protein-folding diseases. Dis Model Mech. 2014 Jan;7(1):3-4. PMID: 24396147 PMCID: PMC3882041
Butterworth MB, Zhang L, Liu X, Shanks RM, Thibodeau PH. Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors. PLoS One. 2014 Jun 25;9(6). PMID: 24963801 PMCID: PMC4070987
Caohuy H, Yang Q, Eudy Y, Ha TA, Xu AE, Glover M, Frizzell RA, Jozwik C, Pollard HS.Activation of 3- phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK 1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of b.f508-cystic fibrosis transmembrane conductance regulator (b.F508-CFTR). J Biol Chem. 2014 Dec 26; 289(52): 35953-68. PMID: 25384981 PMCID: PMC4276863
Carattino, MD, Mueller GM, Palmer LG, Frindt G, Hughey RP, and Kleyman TR. Prostasin interacts with the epithelial sodium channel and facilitates cleavage of the gamma subunit by a second protease. Am J Physiol Renal Physiol. 2014 Nov 1;307(9):F1080-7. PMID: 25209858 PMCID: PMC4216988
Choi SM, McAleer JP, Trevejo-Nunez G, Pociask DA, Armentrout RA, Chen K, Kolls JK. Acute alcohol intoxication impairs MRSA clearance in the lung by impeding epithelial production of Reg3γ. Infect Immun. 2014 Jan 13. PMID: 24421048 PMCID: PMC3993390
Chen J, Kleyman TR, Sheng S. Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module. Am J Physiol Renal Physiol. 2014 Mar;306(5):F561-7. PMID: 24402098 PMCID: PMC3949035
Goetzman ES, Alcorn JF, Bharathi SS, Uppala R, McHugh KJ, Kosmider B, Chen R, Zuo YY, Beck ME, McKinney RW, Skilling H, Suhrie KR, Karunanidhi A, Yeasted R, Otsubo C, Ellis B, Tyurina YY, Kagan VE, Mallampalli RK, Vockley J. Long-chain Acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction. J Biol Chem. 2014 Mar 3. PMID: 24591516 PMCID: PMC4036448
Hendricks MR, Bomberger JM. Who's really in control: microbial regulation of protein trafficking in the epithelium. Am J Physiol Cell Physiol. 2014 Feb;306(3):C187-97. PMID: 24133062 PMCID: PMC3919996
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Heat Shock Protein 70 Inhibitors. 1. 2,5'-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70. J Med Chem. 2014 Feb 27;57(4):1188-207. PMID: 24548207 PMCID: PMC3983365
Klinkenberg D, Long KR, Shome K, Watkins SC, Aridor M. A cascade of ER exit site assembly that is regulated by p125A and lipid signals. J Cell Sci. 2014 Feb 12. PMID: 24522181 PMCID: PMC3986675
Kuhlmann AS, Steckbeck JD, Sturgeon TJ, Craigo JK, Montelaro RC. Unique functional properties of conserved arginine residues in the Lentivirus Lytic Peptide domains of the C-terminal tail of HIV-1 gp41. J Biol Chem. 2014 Feb 4. PMID: 24497632 PMCID: PMC3953275
Locke LW, Myerburg MM, Markovetz MR, Parker RS, Weber L, Czachowski MR, Harding TJ, Brown SL, Nero JA, Pilewski JM, Corcoran TE. Quantitative imaging of airway liquid absorption in cystic fibrosis. Eur Respir J. 2014 Sep;44(3):675-84. PMID: 24743971 PMCID: PMC4150848.
Luz S, Cihil KM, Brautigan DL, Amaral MD, Farinha CM, Swiatecka-Urban A. LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells. J Biol Chem. 2014 May 23;289(21):15080-93. PMID: 24727471 PMCID: PMC4031558.
Manni ML, Robinson KM, Alcorn JF. A tale of two cytokines: IL-17 and IL-22 in asthma and infection. Expert Rev Respir Med. 2014 Feb;8(1):25-42. PMID: 24325586 PMCID: PMC4123209.
Markovetz MR, Corcoran TE, Locke LW, Myerburg MM, Pilewski JM, Parker RS. A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis. PLoS One. 2014 Nov 10;9(11): PMID: 25383714, PMC4226497
Oriss TB, Krishnamoorthy N, Ray P, Ray A. Dendritic cell c-kit signaling and adaptive immunity: implications for the upper airways. Curr Opin Allergy Clin Immunol. 2014 Feb;14(1):7-12. PMID: 24300419 PMCID: PMC4125121.
Robinson KM, McHugh KJ, Mandalapu S, Clay ME, Lee B, Scheller EV, Enelow RI, Chan YR, Kolls JK, Alcorn JF. Influenza A Virus Exacerbates Staphylococcus aureus Pneumonia in Mice by Attenuating Antimicrobial Peptide Production. J Infect Dis. 2014 Mar;209(6):865-75. PMID: 24072844 PMCID: PMC3935471
Steckbeck JD, Deslouches B, Montelaro RC. Antimicrobial peptides: new drugs for bad bugs?. Expert Opin Biol Ther. 2014 Jan;14(1):11-4. PMID: 24206062 PMCID: PMC4109705.
Tran JR, Brodsky JL. The Cdc48-Vms1 complex maintains 26S proteasome architecture. Biochem J. 2014 Mar 15;458(3):459-67. PMID: 24351022 PMCID: PMC4135392
Xu Z, Pissarra LS, Farinha CM, Liu J, Cai Z, Thibodeau PH, Amaral MD, Sheppard DN. Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR. J Physiol. 2014 Mar 3. PMID: 24591578 PMCID: PMC4230770
Zemke A, Shiva S, Burns JL, Moscowitz S, Pilewski JM, Gladwin MT, Bomberger JM. Nitrite modulates bacterial biofilm formation and antibiotic susceptibility. Free Rad Biol Med. 2014 Dec;77:307-16. PMID: 25229185 PMCID: PMC4278422