Education & Training
- Ph.D. in Cell Biology from University of Cape Town, Cape Town, South Africa, 2002
- B.Sc.(Med)(Hons) in Cell Biology from University of Cape Town, Cape Town, South Africa, 1995
- B.Sc. in Zoology from University of Cape Town, Cape Town, South Africa, 1994
Research Interest Summary
Regulation of epithelial ion channels in human kidney and airway by hormonal mechanisms, including microRNAs.
Research Interests
- The regulation of the epithelial sodium channel (ENaC) by trafficking and recycling mechanisms
- Investigating and seeking to understand the regulation of ENaC in two tissues, the distal kidney nephron where upregulation of the channel is associated with volume expansion and hypertension, and human airway where ENaC is linked to Cystic Fibrosis
- How the channel (and related distal nephron transporters) are trafficked to the apical surface membrane in response to a variety of signals, and then what happens to these transporters when they are retrieved from the membrane.
- Investigating the regulation of microRNAs by steroid hormones, including aldosterone, and the impact changes in miR levels have on sodium transport regulation.