Publications

2017

Bertrand CA, Mitra S, Mishra SK, Wang X, Zhao Y, Pilewski JM, Madden DR, Frizzell RA. The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9. Am J Physiol Lung Cell Mol Physiol. 2017. 312(6):L912-L925. PMID:28360110. PMC Journal - In Process.


Chakraborty K, Raundhal M, Chen BB, Morse C, Tyurina YY, Khare A, Oriss TB, Huff R, Lee JS, St Croix CM, Watkins S, Mallampalli RK, Kagan VE, Ray A, Ray P. The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Nat Commun. 2017 Jan 11;8:13944. PMID: 28074841 PMCID: PMC5241690


Corcoran TE, Godovchik J, Donn K, Busick D, Goralski J, Locke LW, Markovetz MR, Myerburg MM, Muthukrishnan A, Weber L, Lacy RT, Pilewski JM. Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis, Ped Pulm 2017 in press.


Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017 Jan;13(1):91-98. PMID: 27842070 . PMC journal in press.


Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Dolben E, Hampton T, Morisseau C, Hammock BD, Liu X, Hogan DA, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host pro-resolving lipid mediators. Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. PMID: 27980032 PMCID: PMC5224368


Gopal R, Rapaka RR, Kolls JK. Immune reconstitution inflammatory syndrome associated with pulmonary pathogens. European respiratory review : an official journal of the European Respiratory Society. 2017 January;26(143). PMID: 28049128. In process. 


Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates. Mol Biol Cell. 2017 May 24. PMID: 28539401 . PMC Journal - In Process.


Kagan VE, Bayır H, Tyurina YY, Bolevich SB, Maguire JJ, Fadeel B, Balasubramanian K. Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids. Biochem Biophys Res Commun. 2017 Jan 15;482(3):482-490. Review. PMID: 28212735 


Lee N, Le Sage V, Nanni AV, Snyder DJ, Cooper VS, Lakdawala SS. Genome-wide analysis of influenza viral RNA and nucleoprotein association. Nucleic Acids Research, 2017. In press


Manni ML, Mandalapu S, Salmeron A, Lora JM, Kolls JK, Alcorn JF. Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease. Scientific reports. 2017 February 24;7:43139. PMID: 28233801; PMCID: PMC5324049.


Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YM, Kolls JK, Anathy V, Alcorn JF. Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection. The American journal of pathology. 2017 April;187(4):851-863. PMID: 28193481 PMCID: PMC5397680


Sharma R, Corcoran TE, Garoff S, Przybycien TM, Tilton RD.  Transport of a partially wetted particle at the liquid/vapor interface under the influence of an externally imposed surfactant generated Marangoni stress, Colloids and Surfaces A:  Physiochemical and Engineering Aspects 2017 521:49-60.  PMID: 28479673, PMC5415349.


Stella NA, Callaghan JD, Zhang L, Brothers KM, Kowalski RP, Huang JJ, Thibodeau PH, Shanks RMQ.  SlpE is a calcium-dependent cytotoxic metalloprotease associated with clinical isolates of Serratia marcescens.  Res Microbiology 2017 Mar 30; S0923-2508(17)30066-9.  PMID:  2836683.  PMC Journal – In Process.


Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R. Identification of BPIFA1/SPLUNC1 as an epitheliumderived smooth muscle relaxing factor. Nature communications. 2017 February 6;8:14118. PMID: 28165446; PMCID: PMC5303822


Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, Wang J. AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.  J Immunol. 2017 Jun 1;198(11):4383-4393. PMID:  28424239 PMCID:PMC5439025

2016

Ahner A, Gong X, Frizzell RA. Divergent signaling via SUMO modification: potential for CFTR modulation. Am J Physiol Cell Physiol. 2016 Feb 1;310(3):C175-80. PMID: 26582473; PMCID: PMC4838058.


Chen K, Eddens T, Trevejo-Nunez G, Way EE, Elsegeiny W, Ricks DM, Garg AV, Erb CJ, Bo M, Wang T, Chen W, Lee JS, Gaffen SL, Kolls JK. IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.  Cell Host Microbe. 2016 Nov 9;20(5):596-605. PMID: 27923703 PMCID: PMC5149406 


Chen K, Kolls JK.  Innate Lymphoid Cells and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Feb 15;193(4):350-2. PMID: 26871668 PMCID: PMC4803088 


Chen K, Campfield BT, Wenzel SE, McAleer JP, Kreindler JL, Kurland G, Gopal R, Wang T, Chen W, Eddens T, Quinn KM, Myerburg MM, Horne WT, Lora JM, Albrecht BK, Pilewski JM, Kolls JK.  Antiinflammatory effects of bromodomain and extraterminal domain inhibition in cystic fibrosis lung inflammation. JCI Insight. 2016 Jul 21;1(11). PMID: 27517095 PMCID: PMC4978187; 


Deslouches B, Hasek M, Craigo J, Steckbeck J, Montelaro R. Comparative functional properties of engineered cationic antimicrobial peptides (ECAPs) consisting exclusively of trypophan and either lysine or arginine. J Med Mecrobiol 2016 June 65; 554-565.  PMID: 27046192 PMCID: PMC5042116.


Ernst WL, Shome K, Wu CC, Gong X, Frizzell RA, Aridor M. VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis. J Biol Chem. 2016 Mar 4;291(10):5206-20.  PMID: 26740627 PMCID: PMC4777854.


Farinha CM, Swiatecka-Urban A, Brautigan DL, Jordan P. Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity. Front Chem. 2016 Jan 20:4:1;  PMID: 26835446. PMCID: PMC4718993


Gong X, Ahner A, Roldan A, Lukacs GL, Thibodeau PH, Frizzell RA. Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation. J Biol Chem. 2016 Jan 22;291(4):2004-17. PMID: 26627832 PMCID: PMC4722474.


Hendricks MR, Lashua LP, Fischer DK, Flitter BA, Eichinger KM, Durbin JE, Sarkar SN, Coyne CB, Empey KM, Bomberger JM. Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1642-7. PMID: 26729873  PMCID: PMC4760822.


Hendricks MR, Bomberger JM. Digging Through the Obstruction: Insight into the Epithelial Cell Response to Respiratory Viral Infection in Cystic Fibrosis. J Virol. 2016 Feb 10; PMID: 26865718 PMCID: PMC4836329


Lakdawala SS, Wu Y, Wawrzusin P, Kabat J, Broadbent AJ, Lamirande EW, Fodor E, Altan-Bonnet N, Shroff H, Subbarao K. Correction: Influenza A Virus Assembly Intermediates Fuse in the Cytoplasm. PLoS pathogens. 2016 December 27;12(12). PMID: 28027316; PMCID: PMC5189951.


Lakdawala SS, Fodor E, Subbarao K. Moving on out: Transport and Packaging of Influenza Viral RNA into Virions. Annual Reviews in Virology 2016 3:411-427. PMID: 27741407


Larsen MB, Hu J, Frizzell RA, Watkins SC. Simple image-based no-wash method for quantitative detection of surface expressed CFTR. Methods. 2016 Mar 1;96:40-5. PMID: 26361332 PMCID: PMC4773656.


Lashua L, Melvin J, Deslouches B, Pilewski J, Montelaro R, Bomberger J. Engineered cationic antimicrobial peptide (eCAP) prevents Pseudomonas aeruginosa biofilm growth on cystic fibrosis airway epithelial cells. J. Antimicrob Chemother. 2016 Aug 71: 2200-2007.  PMID: 27231279  PMCID: PMC4954927.


McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA,Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D,Ouyang W, Hooper LV, Kolls JK. Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome. Journal of immunology (Baltimore, Md. : 1950). 2016 July 1;197(1):97-107. PMID: 27217583; PMCID: PMC4912941.


Melvin J, Montelaro R, Bomberger J. Clinical potential of engineered cationic antimicrobial peptides against drug resistant biofilms. Expert Rev Anti-infect Ther. 2016 Nov 14(11): 989-991.  PMID: 27626708 PMCID: PMC5177990.


Melvin J, Lashua L, Kiedrowski M, Yang G, Deslouches B, Montelaro R, Bomberger J. Simultaneous antibiofilm and antiviral activity of an engineered antimicrobial peptide during viral-bacterial co-infection. mSphere. 2016 May 4; 1(3)e00083-16.  PMID: 27303744  PMCID: PMC4888888.


Moreira ÉA, Weber A, Bolte H, Kolesnikova L, Giese S, Lakdawala S, Beer M, Zimmer G, García-Sastre A, Schwemmle M, Juozapaitis M. A conserved influenza A virus nucleoprotein code controls specific viral genome packaging. Nature Communications. 2016 Sep 21; 7(12861) PMID: 27650413 PMCID: PMC5035998


Muhlebach MS, Clancy JP, Heltshe SL, Ziady A, Kelley T, Accurso F, Pilewski J, Mayer- Hamblett N, Joseloff E, Sagel SD. Biomarkers for cystic fibrosis drug development. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2016 November;15(6):714-723. PMID: 28215711; PMCID: PMC5321565.


Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis. The Journal of infectious diseases. 2016 December 15;214(12):1865-1875. PMID: 27683817; PMCID: PMC5142085.


Pinilla-Vera M, Xiong Z, Zhao Y, Zhao J, Donahoe MP, Barge S, Horne WT, Kolls JK, McVerry BJ, Birukova A, Tighe RM, Foster WM, Hollingsworth J, Ray A, Mallampalli R, Ray P, Lee JS. Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. PloS one. 2016 July 19;11(7):e0159329. PMID: 27434537; PMCID: PMC4951018.


Salomon JJ, Spahn S, Wang X, Füllekrug J, Bertrand CA, Mall MA. Generation and functional characterization of epithelial cells with stable expression of SLC26A9 Clchannels. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 22; PMID: 26801567  PMCID: PMC4888553


Shrestha A, Hendricks MR, Bomberger JM, McClane BA. Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin. mBio. 2016 December 13;7(6).  PMID: 27965452; PMCID: PMC5156305.


Stetten AZ, Moraca G, Corcoran TE, Tristram-Nagle S, Garoff S, Przybycien TM, Tilton RD.  Enabling Marangoni flow at air-liquid interfaces through deposition of aerosolized lipid dispersions, J Colloid Interface Sci. 2016 484:270-278. PMID: 27623189. PMC5075242.


Telles CJ, Decker SE, Motley WW, Peters AW, Mehr AP, Frizzell RA, Forrest JN Jr. Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis. Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C884-C894.  PMID: 27653983;  PMCID: PMC5206301.


Trevejo-Nunez G, Elsegeiny W, Conboy P, Chen K, Kolls JK. Critical Role of IL-22/IL22- RA1 Signaling in Pneumococcal Pneumonia. Journal of immunology (Baltimore, Md. :1950). 2016 September 1;197(5):1877-83. PMID: 27456484; PMCID: PMC4992592.


Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. Mol Biol Cell. 2016 Feb 1;27(3):424-33. PMID: 26823392  PMCID: PMC4751594.


Way EE, Trevejo-Nunez G, Kane LP, Steiner BH, Puri KD, Kolls JK, Chen K. Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor. Scientific reports. 2016 July 27;6:30384. PMID: 27461849; PMCID: PMC4961957.


Zemke AC, Kocak BR, Bomberger JM. Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin. Antimicrob Agents Chemother. 2016 Dec 27;61(1). PMID: 27799207 PMCID: PMC5192113


Zou C, Synan MJ, Li J, Xiong S, Manni ML, Liu Y, Chen BB, Zhao Y, Shiva S, Tyurina YY, Jiang J, Lee JS, Das S, Ray A, Ray P, Kagan VE, Mallampalli RK. LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. Journal of cell science. 2016 January 1;129(1):51-64. PMID: 26604221; PMCID: PMC4732295.


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