Education & Training
- MD, Justus-Liebig-University of Giessen and University of Hamburg, Germany
- Dr. Med., University of Giessen, Germany
- Dr. Phil/PhD, Justus-Liebig University Giessen, Germany
- Internal Medicine Residency and Pulmonary Fellowship, University Hospital Giessen, Department of Medicine, Germany
- Postodoctoral Fellow, Pulmonary, Department of Medicine, University of Giessen Lung Center, Germany
Research Interests
Dr. Königshoff’s research focuses on deciphering mechanisms involved in lung repair and regeneration, with the aim to identify novel therapeutic targets relevant for age-related chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). Her translational research program focuses on the comprehensive characterization of primary lung epithelial (stem) cells from experimental models and human tissue samples from patients with chronic lung disease. She aims to identify and investigate target signaling pathways that impact cellular mechanisms she identified the developmental WNT signaling pathway as a potent contributor to impaired lung repair and epithelial cell reprogramming, which is amenable to therapy and have further characterized features of epithelial cell reprogramming, such as cellular senescence. Dr. Königshoff further pioneered and applies patient-derived 3D Lung Tissue Cultures that allow to further validate and test potential novel drugs in an individualized fashion.