Working at the interface of material, device and biomedicine, Professor Zheng’s research is highly interdisciplinary. His group has developed new nanomaterial constructs, methods for integrating nanomaterials into microdevices, new designs, principles and fabrication for microdevices, and enabling instruments and platforms in critical biomedical areas such as cancer and infectious diseases. A few examples are described as following. (1) During tumorigenesis and metastasis, tumor-derived materials, such as circulating tumor cells (CTCs) and extracellular vesicles (EVs, including exosomes), are released into the blood circulation. Blood assays to detect these cancer markers in blood are referred as liquid biopsy. Working with oncologists, his lab is developing several micro/nano technology platforms to isolate CTCs and EVs from body fluids of cancer patients. The ultimate goal is to translate the technology for cancer diagnosis and patient management. (2) High-performance point-of-care device and system for virus sample preparation and detection are highly desirable for newly emerging viruses that are often zoonotic. His group has been developing nanomaterial-integrated microdevices for virus discovery and diagnostics. (3) The intracellular delivery of bio-functional enzymes or therapeutic proteins through systemic administration is of great importance in therapeutic intervention of various diseases. However, current strategies face substantial challenges owing to various biological barriers. His lab has been working on biomimetic nanoparticles for systemic and intracellular delivery of proteins.