Education & Training
- MD from Washington University, 1978
- B.S. from Syracuse University, 1973
Research Interest Summary
Structure and regulation of epithelial ion channels
Research Interests
- Identification of sites within the channel's extracellular domain that have key roles in the modulation of channel activity in response to extracellular factors, including Na+, shear stress, and proteases.
- Explaining mechanisms by which proteases and external cations regulate epithelial Na+ channel activity
- Exploring via rodent models how variants of novel functional human epithelial Na+ channels affect renal Na+ handling and blood pressure
- Mechanisms by which mechanical forces regulate epithelial sodium channels and large conductance Ca2+ activated potassium channels